Lysosomal Disease Solutions – Amicus Therapeutics

Amicus Therapeutics is seeking to find the cure for a variety of rare and orphan diseases that affect people around the globe. Our primary focus at Amicus Therapeutics is in lysosomal-storage disorders, diseases which affect the function of lysosomes in the human cell. Some examples of these types of diseases include Fabry Disease, Epidermolysis Bullosa, and Pompe Disease, all rare disorders we are conducting research on to find treatments for at Amicus Therapeutics.


Our focus is on targeting specifically mutated proteins. For Fabry Disease, a genetic disease that causes a wide range of symptoms across affected patients, we are developing the oral treatment Migalastat. Migalastat stabilizes the defective enzyme within patients who have the disease, which could become a life-changing monotherapy treatment method for up to 50% of people who suffer from Fabry Disease. Currently, there are treatments to manage Fabry Disease, but they are lifelong and incur significant costs.


Another disease that we are focusing on at Amicus Therapeutics is Epidermolysis Bullosa, a genetic disorder that causes skin blistering and lesions (SeekingAlpha). It is chronic, painful and sometimes even fatal. Our topical treatment, SD-101, is currently in a Phase 3 study, and in 2013 the treatment was one of the first to receive a Breakthrough Therapy designation from the FDA.


The final disease that is currently one of our ongoing focuses for study and trial is Pompe Disease. Pompe Disease is an inherited Lysosomal Storage Disorder (LSD) that is caused by a deficiency of an enzyme that results in the accumulation of glycogen in the lysosomes of muscles and other body tissues. This disease has a high mortality due to the complications that arise from the body not being able to properly store glycogen. Our current treatment prospect is ATB200/AT221 which is a recombinant human enzyme that is administered with a chaperone protein and a carbohydrate structure for optimization. This treatment is currently in the active clinical trial phase.


Amicus Therapeutics is changing the world for patients suffering from rare and orphan diseases ( We are committed to finding the cure for a wide range of rare genetic disorders through our innovative research and passion for our work.

Osteo Relief Institute: A Dream come true for many:

The Osteo Relief Institute is located in Wall Township New Jersey. The facility is easily accessible from the Garden State Parkway and New Jersey Turnpike. The institute uses advanced technology to treat conditions associated with osteoarthritis. The Osteo Relief Institute has trained staff members that will work with each patient to help them regain lost mobility and live a fuller life.


Many patients come to Osteo seeking relief from painful knee conditions. Osteo relief Institute uses the most advanced OA knee treatments available. OA treatments can help reduce pain and inflammation as well as help the patient regain movement.


OA treatment may involve injections directly into the knee area. In addition, mobility exercises may be suggested as part of a treatment regimen. Knee Strengthening by using the Quadricep muscles is quite effective in many patients. Air Squats have also been very helpful when attempting to strengthen muscles around the knee area.


The goal of Osteo Relief Institute is to help patients overcome pain and increase the quality of life without resorting to invasive surgical procedures. Surgery can be quite invasive and recovery can take a considerable amount of time. However, in more severe cases knee replacement surgery may be necessary. The medical team at Osteo Relief Institute will make appropriate recommendations.


The first step is to make an appointment for a complete evaluation and consultation (About). During the evaluation process, a trained staff member will ask a series of questions concerning their condition. In addition, the patient will have the opportunity to address any concerns that he or she may have.


The web site provides a variety of useful information. You can view the Osteo web site at A number of insurance plans are accepted at the Institute. An intake specialist will handle all insurance related matters for new patients.

More about Osteo Relief Institute

Eli Gershkovitch:A Canadian Craft Beer Pioneer


Canadians are passionate about craft beer. Each year the are many craft beer festivals held throughout Ontario. These festivals showcase some of the top small batch craft brewers. One Toronto, Ontario brewing company is set to release an alcohol-free craft beer this fall. Banned from drinking alcohol because he was diagnosed with Crohn’s disease, the owner of the brewing company set out to produce the best alcohol-free craft beer.

That’s just one example of how passionate Canadians are about their beer. Another example is that in Toronto there are 200 ethnic groups, speaking 140 languages and there are 300 craft breweries. Yet the industry is still considered to be in its infancy.


Eli Gershkovitch is a Canadian craft beer brewer. The CEO of Steamworks Brewery, he has been involved in brewing craft beer for over 20 years. It was a trip to visit a number of European breweries in 1987 that got Eli Gershkovitch interested in creating craft beer. He and his partner started off in 1994 with a small brew pub in Gastown.


Gradually, as demand grew, the amount of craft beer Steamworks produced grew to meet the demand. Soon the craft brewery was doing such a brisk business, Gershkovitch added almost 5 times the number of seats in the brew pub. Eventually, he opened a second location in neighboring Waterfront station.


These days Eli Gershkovitch is considered a Canadian craft beer industry pioneer. The former attorney has continued to expand his operations to meet the increased demand. In 2013, Eli Gershkovitch decided he needed to build a full-scale brewery. One with a capacity of 40,000-hectolitre. Now he straddles the limit of what can legally be considered a micro-brewery.


But Eli Gershkovitch is not worried. Steamworks Brewery has seen a dramatic increase in its customer base. There is now an older crowd. It includes more women as well as white-collar and blue-collar workers looking for good, flavorful craft beer. Eli Gershkovitch now sells his craft beer in a number of Canadian provinces, 14 U.S. states and in Austria, Germany, Hong Kong, Italy, and Switzerland. Steamworks Brewery has gone global.

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Increasing Start-up Success is the Goal Of Executive Glen Wakeman

It may seem unusual that someone with 30 years invested in a career would give up a comfortable corporate title and set out on their own. This is the path taken by Financial Services Executive Glen Wakeman. His past work included a role that lasted for more than two decades as a CEO for GE Money in Latin America and many other high-profile positions. In 2015 he founded Launchpad Holdings, LLC and began this new venture with the goal of increasing success rates in viable start-ups. Identifying a Problem Wakeman understands business, finance, and strategy. He stays abreast of the business world and had been drawn to the many start-ups arriving over the last few years. Glen Wakeman could see the value of the ideas or products and was frequently surprised when these enterprises would fail. Through further investigation, it became clear that product development and marketing were used well by these companies, but that many failed to actually create a business plan. Using His Experience Throughout his career, Glen Wakeman has mentored others around him. It was only natural that he take this desire and talent and use it to benefit budding entrepreneurs. Through LaunchPad Holdings he was able to develop and make available a business toolkit that led users through the process of devising a genuine plan. The software is designed to work with any organizations of any size or type and offers additional tips for finding funding as well. Continuing the Effort In addition to his company, Wakeman is also an active blogger, executive mentor, and business advisor ( Glen Wakeman’s past career allowed him the opportunity to travel extensively, live in a number of countries and meet many people. All of this helped him to gain the knowledge needed to understand trends and changes in a global marketplace. Glen Wakeman remains fully involved in the company he founded as well as staying in tune with the fast-paced modern business world. His constant research helps him to remain an effective strategic thinker and he happily shares his ideas to readers of his blog as well as his clients. More here

Equities First Holdings Earns Spot in Top Tier Financial Enterprises

Equities First Holdings specializes in stock-based loans and has become one of the most recognized and innovative financial enterprise. Founded in 2002, Equities First Holdings is a platform for credit services and offers security through the transaction of allowing customers to receive loans with publicly traded stocks. Equities First Holdings differentiates itself by offering the most affordable rates regarding qualification criteria. Customers have been able to achieve their personal and business financial goals, ensuring security throughout each transaction.


The organization provides lending solutions to costumers globally. Equities First Holdings has expanded its office to 7 countries and has managed to transact upwards of $1.4 Billion. The company’s transparent and secure transaction processes has allowed them to pick up high net-worth business owners looking for non-purpose capital and Equities First Holdings lacrosse camp.


The London office has played a huge component in the development and growth of Equities First Holdings. From gaining prestigious clientele to working with Chief Executive of Paysafe PLC, Joel Leoneff, in which it became the second most high publicized repayment of shares. Because of this publicity and success in networking, London has committed $100M to further invest in lending within the European Market and what Equities First Holdings knows.


Equities First Holdings provides the lowest rates on their loan products across the world. The company has been able to accumulate clients through their business model and offering customers fast and secure stock options. The company also provides a fixed interest rate for a set amount of time to ensure the borrower will be able to easily settle the credit.


Equities First Holdings main clients are businesses and high net-worth individuals looking for non-purpose capital. Through their secure and fast options, their customers do not have limits or difficulty in loan repayment. Through credit-based loans, their customers are able to overcome an economic crisis. They’re offered a liquid supply throughout a secure, fast, and transparent process. Click here to view their official website.


Bruno Fagali Legal Advice On Ethical Compliance

The importance of ethical practices in corporations, especially regarding the advertising department cannot be assumed away. The whole domain of a sound, integrity acquainted corporate administration rotates around there being of sound policies and compliance procedures. This is a multifaceted dispensation that requires the attention of experienced legal advisors such as Bruno Fagali. The lawyer’s role in helping organizations adapt to Brazilian ethical compliance statutes, and state laws as well, has been applauded by many clients in Brazil.

Currently, Bruno Fagali is a Corporate Integrity Manager in Nova /SB. His chief role as an integrity conformist has given him a wealth of legal and ethical knowledge, which is valuable to the corporate world.

He also operates independently in his agency named Fagali Law Firm. Fagali advocacy has handled so far some cases regarding administrative law and state law. The lawyer has had top notch legal roles in other law firms since the year 2006.

The Lawyer is an Alma Mater of the University of Sao Paulo where he graduated with a master’s degree in State law in the year 2017. He attended the Pontifical Catholic University of Sao Paulo where he attained his Bachelor’s degree in law and specialized in Administrative law from the same institution.

Bruno Fagali leadership role in Nova/SB was exemplified by the award the company won for upholding compliance. The company won the top prize for compliance from Ethos Institute. The award was a testament to the wealth of knowledge and intellect that the corporate manager has in respect to the ethical law. It is also notable that the company was the first advertising agency to be recognized by Ethos Institute and given such an award.

Bruno Fagali has been very vocal about the scope of unethical practices in the advertising industry, positing on the compliance procedures that need to be put in place to ensure that advertising department does not collide with advertising agencies. He argues things like gifts should not be allowed as they are the windows that permit this malpractice. He also believes that companies ought to lay down sound payment procedures.

Imran Haque: a Doctor with a Big Heart


Dr. Imran Haque operates as an internist around North Carolina. BroTalk has featured him severally for being a specialist with a difference. Apart from being a highly-regarded expert, Imran Haque is also genuinely caring. As such, he has become a wonderful friend to many people within Ramseur and Asheboro. He attends to a broad spectrum of conditions within his specialty, which attracts many patients to his medical amenity. His facility, Horizon Internal Medicine, has become the central point for all people with problems necessitating Imran’s care. Haque amazes many with his kind-hearted nature that brings out a unique trait in him. Imran Haque has received reviews from patients he treated even when they did not have a financial capacity matching their bills.



Essentials Concerning Horizon Internal Medicine



Horizon Internal Medicine serves as the practice where patients in need of internal medication meet Doctor Imran Haque. They operate under the guidance of high integrity as they serve the people of Asheboro, Ramseur, and the whole North Carolina. Mr. Haque and team have proved to be leaders in provision of internal treatment and consultancy. Apart from providing treatment, Dr. Imran is also dependable when it comes to referring his patients to other medics where such needs arise. Upon visiting Horizon Internal Medicine, you will encounter welcoming staffs who are trained on handling every patient. At the facility, Imran Haque diagnoses and prescribes treatment for conditions such as diabetes, glaucoma, pneumonia, and epilepsy.



Haque’s Commitment to Changing People’s Lives



Imran Haque is a unique specialist pursuing extraordinary causes. While other people set such a facility to mint money, Imran Haque operates for entirely different reasons. To him, the amenity gives him an opportune moment to connect with all his patients. He cultivates on a personal relationship with people that visit his medical facility. Besides being an internist for all, most people have booked him as a personal doctor for their families and even parents. Even issues to do with weight management are resolved by Imran, who very well understands the dangers of being overweight.

The Role Alfonso De Angoitia Noriega Plays In the Booming Of Media Sector in Mexico

     The current situation of the media industry in Mexico is evolving day by day. With the government introducing the film tax incentive the media industry is expected to grow both domestically and internationally. The media industry in Mexico that mainly includes film, publications, video games and music has broken the initial barriers that portrayed it as a puppet controlled by the government. The media industry that now mainly encompasses privately owned media companies which are more independent and out spoken especially in political matters. These media enterprises have enhanced their services due to the contemporary technological advancements. Their audiences can also access the services offered simply online. The companies have also established websites, digital games and streaming options for their businesses. These companies are shaping their services to meet their cultural preferences and as a result, have over taken the media industry in Latin America.

Alfonso de Angoitia Noriega, the executive vice chairman at Grupo Televisa. He joined the company in 1999 and was named the foreman of the company’s finance committee. Alfonso de Angoitia Noriega completed his Bachelor of Law at the National Autonomous University of Mexico. He co-founded Mijares a prominent law firm in Mexico. Before becoming the finance officer, he was the personal lawyer to the executive director for the Grupo Televisa and dealt with both the legal and financial structural operations of the company.

Alfonso de Angoitia Noriega oversaw the deal between Grupo Televisa and Univision. He is an active participant of the board of Univision. For five years since 2000, he was the vice president of Grupo Televisa Committee and was named the Vice chairman of the company. In 2015, Alfonso de Angoitia Noriega became a member of the director’s committee at Grupo Financiero Banorte. Alfonso de Angoitia Noriega is the Chairman of the Board of Kardias Foundation.

How Glen Wakeman Came Up With The Idea Of LaunchPad Holdings

Glen Wakeman is the CEO of LaunchPad Holdings, LLC, a company he co-founded in November of 2015. This company is located in the Miami/Fort Lauderdale Area and specializes in helping entrepreneurs succeed through their approach that emphasizes a clear business plan and sufficient liquidity. He has over 30 years of professional experience as a top executive.

It was in 1981 that Glen Wakeman graduated from the University of Scranton with Bachelors of Science degrees in Finance and Economics (Ideamensch). While attending school he was involved in a number of activities such as running the campus radio station, drama club, student government, and playing sports. He went back to school in 1991 at The University of Chicago and graduated with his MBA in Finance in 1991.

Glen Wakeman for over 20 years for GE Money (NewsSky). He was able to eventually earn the position of CEO Latin America where he ran the company’s South American business. While at GE Money he worked primarily internationally and lived in Europe, Asia, and eventually South America.

When he was developing the idea of LaunchPad Holdings, Glen Wakeman was contemplating why most new businesses fail within a few years of being launched. He determined that the usual reason was that the founders lacked structure around their ideas and hadn’t created a solid business plan. He came up with creating a software platform for creating business plans which anyone could use due to its simplicity. Visit his website at

One of the recent improvements in technology involves machine learning. Glen Wakeman says that nowadays there is an enormous amount of information available but the sheer volume of it means that people need the help of AI in order to make sense of it.



Osteo Relief Institute Helps More People Learn How to Handle Their Bodies When Arthritis is a Problem

Not all diseases of the body can be cured, unfortunately. One of those diseases is arthritis. Arthritis occurs over time from the breaking down of various joints and muscles within the body. Right now, there are over 50 million people within the US which are affected by some form of arthritis. Here are some things that the Osteo Relief Institute says you can do to help avoid any further problems down the road.


The first thing that the Osteo Relief Institute wants people to know is that the more weight that you put on your knees, the more problems you are going to have with arthritis. Your knees carry a lot of weight and pressure on them and the heavier that a person is, the more trouble there is with arthritis in the knee. Also know that if you are a smoker, the cigarettes can cause more damage to joints because it attacks the connective tissue in the body. Quit smoking is one way to help counter react aging joints and muscles.

Something else that the Osteo Relief Institute wants you to know is that you have to pace yourself ( You can’t just decide one day to workout without knowing what you are doing or how long you should do something. If you decide that you want to start an exercise plan, make sure you consult your doctor first so you know what things you should do and what you shouldn’t do.


Avoiding repetitive movements is another big thing that the Osteo Relief Institute says you should do to eliminate pain caused by arthritis. For people who overuse a specific joint or muscle in the body, they will start to see more pain in that area. This pain is the swelling and inflammation that a muscle, joint or tendon gets from the over and over the movement. You should try to avoid any repetitive movements if at all possible.


When you decide to start doing activities to build muscles in the body, you will want to choose a specific exercise that will start to build muscle surrounding the joints instead of putting stress on the actual joint. You should focus on the range of motion as well as the stretching of your joints but do it in a gradual process instead of all at once says the Osteo Relief Institute.